June event information is coming soon!
Victor Nizet, MD, Professor & Vice Chair for Basic Research, Department of Pediatrics, Chief, Division of Host-Microbe Systems & Therapeutics, Professor, Skaggs School of Pharmacy & Pharmaceutical Sciences
Dr. Nizet’s laboratory interests lie in understanding the fundamental mechanisms of bacterial pathogenesis and the innate immune system, with a special focus on human streptococcal and staphylococcal infections. Using a variety of molecular genetic approaches, the laboratory discovers and characterizes bacterial virulence factors involved in cytotoxicity, adherence, invasion, inflammation, molecular mimicry and resistance to immunologic clearance. In companion studies, we investigate the contribution of host factors such as antimicrobial peptides, leukocyte surface receptors, signal transduction pathways, and transcription factors in defense against invasive bacterial infection.
We have shown that the basic information gained through this platform can lead to novel treatment strategies for infectious diseases, involving targeted neutralization of bacterial virulence phenotypes and pharmacologic augmentation of host innate immune function. Additional research examines innovative vaccine approaches to prevent infection by leading Gram-positive bacterial pathogens.
Date & Time
Wednesday, June 7, 2017, 5-7 PM